Since at any moment a neuron is likely to have thousands of neurons releasing neurotransmitters at its surface, how is neuronal activity (to fire or not to fire) determined?
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14. The Autonomic Nervous System
Neurotransmitters of the ANS
Problem 11
Textbook Question
Match the following neurotransmitters with their correct description.
_____ GABA
_____ Dopamine
_____ Substance P
_____ Acetylcholine
_____ Glutamate
_____ Endorphins
_____ Norepinephrine
a. Neuropeptide involved in transmission of pain
b. Neurotransmitter released at the neuromuscular junction
c. Major excitatory neurotransmitter in the brain
d. Major inhibitory neurotransmitter in the brain
e. Neuropeptide involved in relief of pain
f. Catecholamine involved in the autonomic nervous system
g. Catecholamine involved in movement and behavior

1
Understand the problem: You are tasked with matching neurotransmitters to their correct descriptions. Each neurotransmitter has a specific role or function in the nervous system, and the descriptions provided correspond to these roles.
Step 1: Identify the neurotransmitter GABA. GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Match GABA with description 'd'.
Step 2: Identify the neurotransmitter Dopamine. Dopamine is a catecholamine involved in movement and behavior. Match Dopamine with description 'g'.
Step 3: Identify the neurotransmitter Substance P. Substance P is a neuropeptide involved in the transmission of pain. Match Substance P with description 'a'.
Step 4: Identify the neurotransmitter Acetylcholine. Acetylcholine is released at the neuromuscular junction and is involved in muscle contraction. Match Acetylcholine with description 'b'.
Step 5: Identify the neurotransmitter Glutamate. Glutamate is the major excitatory neurotransmitter in the brain. Match Glutamate with description 'c'.
Step 6: Identify the neurotransmitter Endorphins. Endorphins are neuropeptides involved in the relief of pain. Match Endorphins with description 'e'.
Step 7: Identify the neurotransmitter Norepinephrine. Norepinephrine is a catecholamine involved in the autonomic nervous system. Match Norepinephrine with description 'f'.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Neurotransmitters
Neurotransmitters are chemical messengers that transmit signals across synapses between neurons. They play a crucial role in regulating various physiological processes, including mood, pain perception, and motor control. Each neurotransmitter has specific functions and effects on the body, influencing everything from emotional responses to muscle contractions.
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Neurotransmitter Receptors
Inhibitory vs. Excitatory Neurotransmitters
Neurotransmitters can be classified as inhibitory or excitatory based on their effects on the postsynaptic neuron. Inhibitory neurotransmitters, like GABA, decrease the likelihood of a neuron firing, while excitatory neurotransmitters, such as glutamate, increase this likelihood. Understanding this distinction is essential for grasping how neurotransmitters influence neural communication and overall brain function.
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Neurotransmitter Receptors
Neuropeptides
Neuropeptides are a type of neurotransmitter that consists of short chains of amino acids. They often function as modulators, influencing the activity of other neurotransmitters and playing roles in pain regulation, stress response, and emotional behavior. Examples include substance P, which is involved in pain transmission, and endorphins, which help alleviate pain and induce feelings of pleasure.
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