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Multiple Choice
Centrally-acting muscle relaxants relieve muscle spasms and pain through which mechanism?
A
By directly inhibiting acetylcholine release at the neuromuscular junction
B
By increasing calcium release from the sarcoplasmic reticulum
C
By depressing activity in the central nervous system
D
By stimulating muscle fiber contraction
Verified step by step guidance
1
Step 1: Understand the role of centrally-acting muscle relaxants. These drugs primarily work on the central nervous system (CNS) rather than directly targeting the muscles or neuromuscular junction.
Step 2: Review the mechanism of acetylcholine release at the neuromuscular junction. Centrally-acting muscle relaxants do not directly inhibit acetylcholine release; this mechanism is more relevant to drugs that act peripherally.
Step 3: Examine the role of calcium release from the sarcoplasmic reticulum in muscle contraction. Centrally-acting muscle relaxants do not increase calcium release; this mechanism is associated with muscle activation rather than relaxation.
Step 4: Focus on the CNS-depressing activity of these drugs. Centrally-acting muscle relaxants reduce the excitability of neurons in the CNS, leading to decreased muscle spasms and pain.
Step 5: Eliminate the option of stimulating muscle fiber contraction, as this would increase muscle activity rather than relax it. Centrally-acting muscle relaxants aim to reduce muscle activity by modulating CNS activity.