Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

17. The Blood

Erythrocytes: Hemoglobin

Anatomy & Physiology

17. The Blood

Erythrocytes: Hemoglobin

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Multiple Choice

What is the significance of the sigmoidal shape of the oxygen-hemoglobin dissociation curve?

It indicates a linear relationship between oxygen partial pressure and hemoglobin saturation.

It shows that hemoglobin saturation is independent of changes in pH and temperature.

It suggests that hemoglobin has a low affinity for oxygen at all partial pressures.

It allows for efficient oxygen loading in the lungs and unloading in the tissues.

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Verified step by step guidance

Understand the oxygen-hemoglobin dissociation curve: This curve represents the relationship between the partial pressure of oxygen (pO2) and the saturation of hemoglobin with oxygen. It is typically sigmoidal (S-shaped) in nature.

Recognize the significance of the sigmoidal shape: The sigmoidal shape indicates cooperative binding, meaning that the binding of one oxygen molecule to hemoglobin increases the affinity for the next oxygen molecule. This is due to conformational changes in the hemoglobin molecule.

Identify the implications for oxygen loading and unloading: In the lungs, where the pO2 is high, hemoglobin binds oxygen efficiently. In tissues, where the pO2 is lower, hemoglobin releases oxygen more readily. This is facilitated by the steep portion of the curve.

Consider the effects of physiological factors: The curve can shift based on factors like pH (Bohr effect), temperature, and levels of 2,3-bisphosphoglycerate (2,3-BPG). These shifts affect hemoglobin's affinity for oxygen, enhancing unloading in tissues or loading in the lungs.

Conclude the significance: The sigmoidal shape of the curve is crucial for efficient oxygen transport, allowing hemoglobin to load oxygen in the lungs and unload it in tissues, adapting to varying physiological conditions.