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Multiple Choice
Which of the following correctly represents the first step in the process of skeletal muscle contraction?
A
Power stroke of the myosin head
B
Release of acetylcholine at the neuromuscular junction
C
Binding of calcium to troponin
D
Detachment of myosin from actin
Verified step by step guidance
1
Understand the process of skeletal muscle contraction, which begins at the neuromuscular junction where a motor neuron communicates with a muscle fiber.
Recognize that the first step involves the release of acetylcholine (ACh), a neurotransmitter, from the motor neuron into the synaptic cleft at the neuromuscular junction.
Learn that acetylcholine binds to receptors on the muscle cell membrane (sarcolemma), leading to the opening of ion channels and the generation of an action potential in the muscle fiber.
Understand that the action potential travels along the sarcolemma and into the T-tubules, triggering the release of calcium ions from the sarcoplasmic reticulum into the cytoplasm of the muscle cell.
Note that calcium ions bind to troponin, causing a conformational change that moves tropomyosin away from the binding sites on actin, allowing the myosin heads to interact with actin and initiate contraction.