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Multiple Choice
Which event must occur first during endochondral ossification?
A
Invasion of the periosteal bud
B
Formation of the medullary cavity
C
Development of a cartilage model
D
Deposition of bone matrix by osteoblasts
Verified step by step guidance
1
Understand the concept of endochondral ossification: This is the process by which bone tissue is formed from a cartilage model. It is the primary method of bone formation for long bones in the body.
Identify the sequence of events in endochondral ossification: The process begins with the development of a cartilage model, followed by other steps such as calcification, invasion of the periosteal bud, and deposition of bone matrix by osteoblasts.
Focus on the first event: The development of a cartilage model is essential because it provides the initial framework for bone formation. Without this model, subsequent steps cannot occur.
Relate the role of chondrocytes: Chondrocytes are responsible for producing the cartilage matrix during the initial stage of endochondral ossification. This matrix will later be replaced by bone tissue.
Recognize the importance of the cartilage model: The cartilage model serves as a scaffold for the deposition of bone matrix by osteoblasts, which occurs later in the process. This highlights why the development of the cartilage model must occur first.