Here are the essential concepts you must grasp in order to answer the question correctly.
pH Regulation in the Duodenum
The duodenum, the first part of the small intestine, plays a crucial role in digestion and requires a specific pH range for optimal enzyme activity. A drop in pH below 4.5 indicates increased acidity, which can harm intestinal lining and disrupt digestive processes. This triggers physiological responses to restore a more neutral pH.
Recommended video:
Secretin
Secretin is a hormone produced by the S cells in the duodenum in response to acidic chyme. Its primary function is to stimulate the pancreas to release bicarbonate, which neutralizes stomach acid, and to inhibit gastric acid secretion. This helps maintain the appropriate pH for digestive enzymes to function effectively.
Cholecystokinin (CCK)
Cholecystokinin is a hormone released by the I cells in the duodenum in response to fatty acids and amino acids. While its primary role is to stimulate gallbladder contraction and pancreatic enzyme secretion, it also plays a part in regulating gastric emptying and promoting satiety. CCK's release can be influenced by changes in pH, but it is not directly stimulated by low pH.
Recommended video: