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Multiple Choice
Which of the following is an activity of the pyruvate dehydrogenase complex?
A
Decarboxylation of pyruvate to acetyl-CoA
B
Conversion of acetyl-CoA to citrate
C
Phosphorylation of glucose to glucose-6-phosphate
D
Oxidation of NADH to NAD+
Verified step by step guidance
1
Understand the role of the pyruvate dehydrogenase complex (PDC) in cellular respiration. It is a crucial enzyme complex that links glycolysis to the citric acid cycle by converting pyruvate into acetyl-CoA.
Identify the main reaction catalyzed by the pyruvate dehydrogenase complex. The PDC facilitates the decarboxylation of pyruvate, which means it removes a carbon dioxide molecule from pyruvate.
Recognize that the decarboxylation of pyruvate results in the formation of acetyl-CoA, which is then used in the citric acid cycle to produce energy.
Differentiate between the activities listed in the problem. The conversion of acetyl-CoA to citrate occurs in the citric acid cycle, not by the PDC. Phosphorylation of glucose to glucose-6-phosphate is a step in glycolysis, and oxidation of NADH to NAD+ is part of the electron transport chain.
Conclude that the activity specific to the pyruvate dehydrogenase complex is the decarboxylation of pyruvate to form acetyl-CoA, as it directly involves the transformation of pyruvate into a form that can enter the citric acid cycle.