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Multiple Choice
Which of the following organs is involved in the synthesis of vitamin D?
A
Liver
B
Kidney
C
Skin
D
Pancreas
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1
Understand the role of each organ in the synthesis of vitamin D. The skin, liver, and kidneys are involved in this process.
Recognize that the synthesis of vitamin D begins in the skin. When the skin is exposed to sunlight, specifically UVB radiation, it converts 7-dehydrocholesterol to previtamin D3.
Note that previtamin D3 is then converted to vitamin D3 (cholecalciferol) in the skin through a heat-dependent process.
Understand that the liver is the next organ involved, where vitamin D3 is hydroxylated to form 25-hydroxyvitamin D (calcidiol).
Finally, the kidneys convert 25-hydroxyvitamin D to the active form, 1,25-dihydroxyvitamin D (calcitriol), through another hydroxylation process.