A pleiotropic genetic disorder typically has what characteristics?
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29. Heredity
Patterns of Inheritance
Problem 15
Textbook Question
A normally pigmented woman whose father was an albino marries a normally pigmented man whose mother was an albino. What is the probability that they would have an albino child?
(a) 50 percent
(b) 25 percent
(c) 12.5 percent
(d) 6.25 percent
(e) 100 percent

1
Step 1: Understand the genetic basis of albinism. Albinism is typically inherited as an autosomal recessive trait, meaning that an individual must inherit two copies of the recessive allele (aa) to express the condition. A person with normal pigmentation can be a carrier (Aa) if they have one recessive allele and one dominant allele.
Step 2: Determine the genotypes of the parents based on the information provided. The woman is normally pigmented but her father was an albino, so her genotype must be heterozygous (Aa). Similarly, the man is normally pigmented but his mother was an albino, so his genotype must also be heterozygous (Aa).
Step 3: Set up a Punnett square to analyze the possible genetic combinations of the offspring. Each parent contributes one allele to the child. The possible combinations are: AA (normal pigmentation), Aa (carrier with normal pigmentation), Aa (carrier with normal pigmentation), and aa (albino).
Step 4: Calculate the probability of each genotype. From the Punnett square, there is a 1 in 4 chance (25%) that the child will inherit two recessive alleles (aa) and be albino.
Step 5: Verify the probability and match it to the answer choices provided. The probability of having an albino child is 25%, which corresponds to option (b).

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Genetics and Inheritance Patterns
Understanding basic genetics is crucial for this question, particularly the concepts of dominant and recessive traits. Albinism is typically a recessive trait, meaning that an individual must inherit two copies of the albino allele (one from each parent) to express the condition. The inheritance pattern follows Mendelian principles, where traits are passed from parents to offspring based on allele combinations.
Recommended video:
Autosomal Inheritance
Punnett Squares
A Punnett square is a tool used to predict the genetic outcomes of a cross between two individuals. By mapping the alleles of each parent, one can visualize the potential genotypes of their offspring. This method is essential for calculating the probability of specific traits, such as albinism, in the children of the couple described in the question.
Recommended video:
X-Linked Inheritance
Probability in Genetics
Probability in genetics involves calculating the likelihood of inheriting certain traits based on allele combinations. In this scenario, understanding how to determine the probability of having an albino child requires knowledge of the parents' genotypes and the possible combinations of alleles. This concept is fundamental for arriving at the correct answer regarding the likelihood of albinism in their offspring.
Recommended video:
Genetic Code
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