Evaluate the following statements related to the synthesis of nucleic acids. Select True or False for each statement.T/F Ribonucleotides are added to the 3′ end of a DNA strand.T/F Polymerization of nucleic acids occurs by the formation of phosphodiester bonds.T/F Complementary pairing between sugars is required for copying nucleic acids.T/F Strands in a double helix are synthesized in an antiparallel orientation.
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Identify the components involved in the synthesis of nucleic acids, such as ribonucleotides, DNA strands, and phosphodiester bonds.
Understand the directionality of nucleic acid synthesis, specifically that nucleotides are added to the 3′ end of a pre-existing strand during DNA replication.
Recognize the role of phosphodiester bonds in connecting nucleotides together during the polymerization process of nucleic acids.
Evaluate the statement about complementary pairing by recalling that complementary base pairing occurs between nucleotide bases (adenine with thymine or uracil, and cytosine with guanine), not sugars.
Review the concept of antiparallel orientation in DNA strands, meaning that one strand runs in a 5′ to 3′ direction and the other in a 3′ to 5′ direction.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Nucleic Acid Synthesis
Nucleic acid synthesis refers to the process by which nucleotides are assembled to form nucleic acids like DNA and RNA. This process involves the addition of nucleotides to a growing strand, where ribonucleotides are specifically added to RNA strands, while deoxyribonucleotides are added to DNA strands. Understanding this process is crucial for evaluating statements about the directionality and mechanisms of nucleic acid formation.
Phosphodiester bonds are the covalent linkages that connect nucleotides in a nucleic acid strand. These bonds form between the phosphate group of one nucleotide and the hydroxyl group on the sugar of another, creating a backbone that is essential for the structural integrity of DNA and RNA. Recognizing the role of phosphodiester bonds is vital for understanding how nucleic acids are polymerized.
Antiparallel orientation refers to the arrangement of the two strands in a double helix, where one strand runs in the 5′ to 3′ direction and the other runs in the 3′ to 5′ direction. This orientation is critical for the complementary base pairing that occurs during DNA replication and transcription. Understanding this concept is essential for evaluating the synthesis and functionality of nucleic acids.