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Multiple Choice
Which of the following statements is true regarding the interaction between CD40 and CD40 ligand?
A
CD40 ligand is primarily expressed on B cells and interacts with CD40 on T cells.
B
CD40 ligand is a soluble protein that circulates freely in the bloodstream.
C
The interaction between CD40 and CD40 ligand is crucial for B cell activation and antibody production.
D
CD40 is a cytokine that binds to CD40 ligand to initiate apoptosis in immune cells.
Verified step by step guidance
1
Understand the roles of CD40 and CD40 ligand in the immune system. CD40 is a receptor found on the surface of B cells, while CD40 ligand (also known as CD40L or CD154) is primarily expressed on activated T cells.
Recognize the importance of the interaction between CD40 and CD40 ligand. This interaction is crucial for the activation of B cells, which leads to their proliferation and differentiation into plasma cells that produce antibodies.
Clarify the incorrect statements: CD40 ligand is not primarily expressed on B cells; it is expressed on T cells. CD40 ligand is not a soluble protein; it is a membrane-bound protein on T cells.
Identify the correct statement: The interaction between CD40 and CD40 ligand is essential for B cell activation and antibody production, which is a key process in the adaptive immune response.
Understand that CD40 is not a cytokine, and its interaction with CD40 ligand does not initiate apoptosis in immune cells. Instead, it promotes survival and activation of B cells.