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Multiple Choice
Marfan syndrome is inherited in an autosomal dominant pattern. Which of the following is true?
A
An individual with one affected parent has a 50% chance of inheriting the disorder.
B
The disorder is more common in males than females.
C
Both parents must carry the gene for the disorder to be passed on.
D
The disorder skips generations due to carriers.
Verified step by step guidance
1
Understand the inheritance pattern: Marfan syndrome is inherited in an autosomal dominant pattern, meaning only one copy of the altered gene is needed for an individual to be affected.
Recognize the implications of autosomal dominant inheritance: If one parent has the disorder, they have one affected allele and one normal allele. The other parent has two normal alleles.
Calculate the probability of inheritance: When an affected parent (heterozygous) and an unaffected parent (homozygous normal) have a child, there is a 50% chance the child will inherit the affected allele.
Clarify misconceptions: Autosomal dominant disorders do not skip generations because carriers are affected. Both parents do not need to carry the gene for the disorder to be passed on.
Address gender prevalence: Autosomal dominant disorders like Marfan syndrome are not typically more common in one gender over another, as the gene is located on one of the autosomes, not sex chromosomes.