Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

4. Tissues & Histology

Introduction to Tissues & Histology

Anatomy & Physiology

4. Tissues & Histology

Introduction to Tissues & Histology

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Problem 14

Textbook Question

Which tissues undergo regeneration? Which tissues undergo fibrosis? Why?

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Understand the difference between regeneration and fibrosis: Regeneration is the process by which damaged tissues are replaced with the same type of cells, restoring normal function. Fibrosis, on the other hand, involves the replacement of damaged tissue with scar tissue (composed mainly of collagen), which does not restore normal function.

Identify tissues that undergo regeneration: Tissues with a high capacity for regeneration include epithelial tissues (e.g., skin, mucous membranes), bone, and liver tissue. These tissues have a high mitotic rate or contain stem cells that can divide and replace damaged cells.

Identify tissues that undergo fibrosis: Tissues with a limited capacity for regeneration, such as cardiac muscle, nervous tissue in the central nervous system, and skeletal muscle, often undergo fibrosis. This is because these tissues lack sufficient stem cells or have a very low mitotic rate, making it difficult to replace damaged cells with the same type.

Explain why some tissues regenerate while others undergo fibrosis: The ability of a tissue to regenerate depends on the presence of stem cells and the mitotic activity of its cells. Tissues with abundant stem cells or high mitotic activity can regenerate effectively. In contrast, tissues with limited or no stem cells rely on fibroblasts to produce collagen, leading to fibrosis.

Summarize the functional implications: Regeneration restores the original structure and function of the tissue, while fibrosis results in scar formation, which may compromise the tissue's functionality. For example, fibrosis in the heart after a myocardial infarction can impair its ability to pump blood effectively.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Tissue Regeneration

Tissue regeneration refers to the process by which certain tissues can fully restore their structure and function after injury. This ability is most prominent in tissues such as liver, skin, and some types of muscle. Regenerative capacity is influenced by factors like the type of cells involved, the extent of the injury, and the organism's age and health.

Fibrosis

Fibrosis is the process by which damaged tissue is replaced by fibrous connective tissue, leading to scarring and loss of function. This occurs in tissues that have limited regenerative capacity, such as the heart and lungs, often as a response to chronic injury or inflammation. Fibrosis can impair organ function and is a common feature in various diseases.

Factors Influencing Regeneration vs. Fibrosis

The balance between regeneration and fibrosis is influenced by several factors, including the type of tissue, the severity of the injury, and the presence of inflammatory signals. Tissues with a high regenerative capacity typically have a rich supply of stem cells and a favorable microenvironment, while those prone to fibrosis often experience chronic inflammation and inadequate cellular responses, leading to scarring.

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Related Practice

Multiple Choice

Which of the following statements is true?

Which of the following is something that a histologist would NOT be expected to do?

Each of the following statements is false. Correct each to make a true statement.

The cutaneous membrane is composed of simple squamous epithelium, loose connective tissue, and dense irregular connective tissue.

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Textbook Question

Each of the following statements is false. Correct each to make a true statement.

Serous membranes line all hollow organs that open to the outside of the body.

If you were to cut through epithelial tissue without penetrating the basement membrane, would you expect bleeding to occur? Why or why not?

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Textbook Question

Predict what would happen if the mucous membranes of the body stopped secreting mucus or if they secreted excess mucus.

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Textbook Question

Why do you think the rate of cell division is different for different tissues? Where in the body would you expect to find cells that have a rapid rate of division? Where might you find cells that have a slow rate of division? Explain.

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Textbook Question

Tight junctions make the spaces between cells____, whereas desmosomes increase the ____ of a tissue.

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