Which of the following statements about bile is true?
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23. The Digestive System
The Gallbladder
Problem 15
Textbook Question
The primary hormone that triggers the secretion of pancreatic juice and bile is:
a. Gastric inhibitory peptide
b. Cholecystokinin
c. Motilin
d. Somatostatin

1
Understand the role of pancreatic juice and bile in digestion. Pancreatic juice contains enzymes that help break down carbohydrates, proteins, and fats, while bile aids in the emulsification of fats.
Review the functions of the listed hormones: Gastric inhibitory peptide (GIP) primarily inhibits gastric motility and secretion, cholecystokinin (CCK) stimulates the release of bile and pancreatic enzymes, motilin regulates gastrointestinal motility, and somatostatin inhibits the secretion of various hormones and digestive enzymes.
Focus on the hormone that directly stimulates the secretion of pancreatic juice and bile. Cholecystokinin (CCK) is released in response to the presence of fats and proteins in the small intestine and triggers the gallbladder to release bile and the pancreas to secrete digestive enzymes.
Eliminate the incorrect options based on their primary functions: Gastric inhibitory peptide (a) does not stimulate bile or pancreatic juice secretion, motilin (c) is involved in motility rather than secretion, and somatostatin (d) inhibits secretion rather than stimulating it.
Conclude that the correct answer is the hormone responsible for stimulating both bile and pancreatic juice secretion, which is cholecystokinin (b).

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Cholecystokinin (CCK)
Cholecystokinin is a peptide hormone produced by the cells in the duodenum in response to the presence of fats and proteins. It plays a crucial role in digestion by stimulating the gallbladder to contract and release bile, as well as prompting the pancreas to secrete digestive enzymes. Understanding CCK is essential for recognizing its function in the digestive process.
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Pancreatic Juice
Pancreatic juice is a digestive fluid produced by the pancreas that contains enzymes such as amylase, lipase, and proteases. These enzymes are vital for breaking down carbohydrates, fats, and proteins in the small intestine. The secretion of pancreatic juice is primarily stimulated by hormones like cholecystokinin, making it important to understand its role in digestion.
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Pancreas
Bile
Bile is a digestive fluid produced by the liver and stored in the gallbladder, primarily composed of bile salts, cholesterol, and bilirubin. It is essential for the emulsification and absorption of dietary fats in the small intestine. The release of bile is triggered by hormones such as cholecystokinin, highlighting its importance in the digestive process.
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