Indicate the function of the stellate macrophages and the hepatocytes of the liver.

Stellate macrophages, also known as Kupffer cells, are specialized immune cells located in the liver sinusoids. Their primary function is to phagocytize pathogens, dead cells, and debris, helping to maintain liver health and immune defense. They also play a role in modulating inflammation and liver regeneration.

Hepatocytes are the main functional cells of the liver responsible for a wide range of metabolic, detoxification, and synthetic activities. They produce bile, synthesize plasma proteins like albumin, metabolize nutrients, and detoxify harmful substances. Hepatocytes also store glycogen and regulate blood glucose levels.

The liver microenvironment involves interactions between hepatocytes, stellate macrophages, and other cells to maintain liver function. Kupffer cells help clear pathogens and signal hepatocytes during injury, while hepatocytes perform metabolic tasks. This cooperation ensures effective detoxification, immune response, and tissue repair.