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  • Reproductive role of female more complex because of _____________.


    Pregnancy

  • Internal genitalia: located in pelvic cavity. Includes ____ and _____ _____(____tubes, _____, and ______)


    ovaries and duct system

    (uterine tubes, uterus and vagina)

  • ____ ligament: anchors ovary medially to uterus

    ____ ligament: anchors ovary laterally to pelvic wall

    _____: suspends ovary


    Ovarian

    Suspensory

    Mesovarium

  • The ____ ligament and mesovarium are part of ____ ____ that supports uterine tubes, uterus and vagina.


    Suspensory

    Broad Ligament

  • ______ ______(branches off abdominal aorta)


    Ovarian arteries

  • ______ branch of the ______ _____: vessels travel through suspensory ligament and mesovaria.


    Ovarian Branch of the Uterine arteries

  • Each ovary is surrounded by fibrous _____ _____.

    Then covered by _____ _____ outer layer.

    -Surface epithelium is a continuation of the ______.


    Tunica albuginea

    Surface Epithelium

    peritoneum

  • Outer cortex of the ovary house forming ______.

    Inner ______ contains large blood vessels and nerves.


    gametes

    medulla

  • _______ _______: Tiny saclike structures embedded in cortex.


    ovarian follicles

  • Uterine tube system does not have direct contact with ______.


    ovaries

  • _____ oocyte is released into ____ ____, where some oocytes never make it to tube system.


    ovulated

    Peritoneal cavity

  • The uterine tube system includes _____ _____, _____ and _____.


    uterine tubes, uterus and vagina

  • Regions of the uterine tube:


    Infundibulum

    ampulla

    isthmus

  • The _____ is a funnel shaped opening into the peritoneal cavity,


    Infundibulum

  • Margin contains ciliated projections called ______ that drape over the ovary


    fimbriae

  • ______ forms half of uterine tube length, where _____ usually occurs


    Ampulla

    fertilization

  • ______: Narrow medial third that empties into superolateral region of the uterus.


    Isthmus

  • _______ ________: When oocyte is fertilized in peritoneal cavity or distal uterine tube and begins developing there.


    Ectopic pregnancy

  • Spread of infection from reproductive tract to peritoneal cavity.


    Pelvic Inflammatory Disease (PID)

  • PID may cause _____ _____ and lead to _____.


    scar tissue

    infertility

  • Hollow, thick walled, muscular organ


    uterus

  • The function of the uterus is to _____, _____ and _____ fertilized ovum.


    Receive, retain and nourish

  • What are the 4 regions of the uterus?


    Body

    Fundus

    Isthmus

    Cervix

  • Major portion of the uterus


    Body

  • Rounded superior region of the uterus


    Fundus

  • Narrowed inferior region of the uterus:


    Isthmus

  • Narrow neck, or outlet of uterus that projects into vagina


    Cervix

  • Cervical cancer affects ____ women each year, killing ____.

    -Most common between ages ___ and ___


    450,000

    half

    30 to 50

  • Cervical cancer prevention:

    _______: Three dose vaccine, projects against HPV.

    • For girls ages ____ to ____

    ____ ____: for Detection


    Gardasil

    11 to 12

    Pap smear

  • _____ of the _____:

    Unsupported uterus sinks inferiorly, until tip of cervix protrudes through the external vaginal opening


    Prolapse of the Uterus

  • What causes prolapse of uterus?


    Overstretching or tearing of muscles during childbirth

  • Layers of the Uterine wall:

    _____: outermost serous layer

    _____: bulky middle layer consisting of interlacing layers of smooth muscle

    - Contracts _______ during childbirth.

    _____: Simple columnar epithelium on top of a thick lamina propria


    Peritoneum (visceral peritoneum)

    Myometrium

    -Rhythmically

    Endometrium

  • Fertilized egg burrows into _____ and resides there during development


    endometrium

  • Functions of Vagina:

    • ______ ______

    • Passageway for _____ _____

    • Organ of ______


    Birth Canal

    menstrual flow

    Copulation

  • Vagina Wall:

    • Fibroelastic _____

    • Smooth muscle _____

    • _____ _____ mucosa with rugae


    adventitia

    muscularis

    stratified squamous

  • External genitalia:

    • _____ ____

    • _____ ____

    • _____ ____

    • _____ ____

    • Greater _____ _____

    • _____

    • Bulb of the _____


    • Mons Pubis

    • Labia Majora

    • Labia Minora

    • Vestibule

    • Greater vestibular glands

    • Clitoris

    • Bulb of the vestibule

  • fatty area overlying pubic symphysis


    mons pubis

  • _____ _____: hair covered, fatty skin folds

    -Counterpart of male scrotum


    Labia Majora

  • What are the skin folds that lie within the labia majora?


    Labia minora

  • What is the recess within labia minora?


    vestibule

  • The _____ _____ glands, flank the vaginal opening


    greater vestibular glands

  • ____ ____ ____: along the sides of the orifice; fill with blood during sexual arousal.


    Bulb of vestibule

  • what glands usually only functions in females?


    mammary glands

  • Mammary glands are modified _____ glands consisting of ___ to ___ lobes.


    sweat glands

    15-25

  • Lobules within lobes contain _____ _____


    glandular alveoli

  • Glandular alveoli produce what?


    milk

  • What determines breast size?


    amount of fat deposits

  • pigmented skin surrounding nipple


    areola

  • Second most common cause of cancer death in the US in women.

    • __% of women will develop this condition


    Invasive breast cancer

    13

  • Breast cancer usually arises from ____ cells of ____ ducts that eventually metastasize


    epithelial cells of smallest ducts

  • Risk factors for Breast cancer:

    • Early onset of ____ and late ____.

    • No ____, or first one, late in life.

    • No, or short periods of _____ _____.

    • Family ____ of breast cancer.


    • menstruation and late menopause

    • pregnancy

    • breast feeding

    • history

  • Drugs for estrogen-responsive cancers:

    • _____

    • _____


    anastrozole

    letrozole

  • Production of female gametes


    Oogenesis

  • oogenesis begins in ____ period


    fetal

  • _____ follicles are the first to develop in fetus


    primordial

  • functional unit of ovary that encloses a single oocyte


    ovarian follicle

  • Before ovulation, ____ oocyte inside _____ follicle, resumes ____ and becomes _____ oocyte


    Primary

    vesicular

    meiosis

    secondary

  • Ovulation is caused by _____ hormonal levels, especially ___.

    • One from this group is selected each month to become ____ ____


    High

    FSH

    dominant follicle

  • ____:

    large cell with enough cytoplasm to nourish fertilized egg for ___ to ___ journey to uterus.


    ovum

    6-7

  • Small cell lacking cytoplasm degenerates and dies.


    Second Polar Body

  • ____ phase:

    Period of vesicular follicle growth (days __ - __)


    Follicular phase

    1-14

  • ____ phase:

    period of corpus luteum activity (days __-__)


    luteal phase

    14-28

  • What percentage of women have a 28 day cycle?


    10-15%

  • _____ phase varies, but luteal phase is always ____ days from ovulation to end of cycle.


    Follicular

    14

  • FSH levels drop around middle of follicular phase.

    • _____ follicle outcompetes other follicles and is the only one to continue on.

    • Other non-dominant follicles will undergo _____


    dominant

    atresia

  • after ovulation, ruptured follicle collapses and ____ fills with _____ _____ , that will eventually be ____.


    atrium

    clotted blood

    absorbed

  • Remaining granulosa cells and internal thecal cells enlarge to form the ____ ____.


    corpus luteum

  • The ____ ____ secretes progesterone and some estrogen


    Corpus luteum

  • If no pregnancy occurs, ____ ____ degenerates into ____ ____ (scar) in __ days.

    • endometrium begins to ____


    Corpus luteum

    corpus albicans

    10

    erode

  • If pregnancy occurs, Corpus luteum produces hormones that ____ pregnancy, until placenta takes over at about __ months.


    sustain

    3

  • Shortly after ovulation:

    • ____ levels decline

    • LH transforms ruptured follicle into ____ ____.

    • LH stimulates corpus luteum to secrete ____ and some ____ almost immediately.


    estrogen

    corpus luteum

    progesterone and estrogen

  • If no fertilization, corpus luteum _____.


    degenerates

  • Cyclic series of changes in endometrium that occur in response to fluctuating ovarian hormone levels.


    Uterine (Menstrual) cycle

  • Menstrual cycle : 3 phases:

    • Days __-__: menstrual phase

    • Days __-__: proliferative (preovulatory) phase

    • Days __-__: secretory (postovulatory) phase


    1-5

    6-14

    15-28

  • What promotes oogenesis and follicle growth in ovary?


    estrogen

  • Estrogen:

    • exert ____ effect on female reproductive tract.

    • Causes _____ _____, _____, and _____ to enlarge and become more functional


    anabolic

    uterine, tubes, uterus and vagina