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Anatomy & Physiology: Endocrine System and Blood

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  • Endocrine System

    A collection of glands and tissues that secrete hormones directly into the bloodstream to regulate body functions and maintain homeostasis.

  • Hormone

    A chemical messenger produced by endocrine glands that travels through the blood to affect distant target cells.

  • Target Cell

    A cell with specific receptors that respond to a particular hormone.

  • Negative Feedback

    A regulatory mechanism where a change triggers a response that counteracts the initial change to maintain homeostasis.

  • Pituitary Gland

    Known as the "master gland," it secretes hormones that regulate other endocrine glands.

  • Thyroid Hormones

    Thyroxine (T4) and Triiodothyronine (T3) regulate metabolism and require iodine for synthesis.

  • Parathyroid Hormone (PTH)

    Increases blood calcium by stimulating osteoclasts to break down bone tissue.

  • Water-Soluble Hormones

    Hormones that cannot cross the plasma membrane and bind to cell surface receptors (e.g., peptide hormones, catecholamines).

  • Lipid-Soluble Hormones

    Hormones that can cross the plasma membrane and bind to intracellular receptors (e.g., steroid hormones, thyroid hormones).

  • cAMP (Cyclic Adenosine Monophosphate)

    A common second messenger in hormone signaling that activates protein kinases.

  • Hypothalamic-Pituitary Axis

    Brain region where the hypothalamus controls the pituitary gland via releasing and inhibiting hormones.

  • ADH (Antidiuretic Hormone)

    Regulates water balance by increasing water reabsorption in the kidneys.

  • Growth Hormone (GH)

    Stimulates growth and metabolism; excess causes gigantism in children and acromegaly in adults.

  • Aldosterone

    Adrenal hormone that regulates sodium and potassium balance.

  • Cortisol

    Stress hormone from the adrenal cortex that increases blood glucose levels.

  • Melatonin

    Hormone secreted by the pineal gland that regulates circadian rhythms and sleep-wake cycles.

  • Insulin

    Pancreatic hormone that lowers blood glucose by promoting cellular uptake and glycogenesis.

  • Glucagon

    Pancreatic hormone that raises blood glucose by promoting glycogenolysis and gluconeogenesis.

  • Erythrocyte (Red Blood Cell)

    Cell that transports oxygen and carbon dioxide in the blood.

  • Hemoglobin

    Oxygen-carrying protein in erythrocytes containing iron in the heme group.

  • Hematopoiesis

    Formation of blood cells in the red bone marrow.

  • Platelet (Thrombocyte)

    Cell fragment involved in blood clotting and hemostasis.

  • Hemostasis

    Process to stop bleeding involving vascular spasm, platelet plug formation, and coagulation.

  • Coagulation Cascade

    Sequence: Prothrombin → Thrombin → Fibrinogen → Fibrin forms a stable clot.

  • ABO Blood Group

    Classification based on presence of A and B antigens on red blood cells.

  • Rh Factor

    Presence (+) or absence (−) of the D antigen on red blood cells.

  • Universal Donor Blood Type

    O− blood type; lacks A, B, and Rh antigens, can donate to any blood type.

  • Universal Recipient Blood Type

    AB+ blood type; has all antigens and can receive from any blood type.