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Cardiovascular and Blood System Fundamentals

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  • Functions of the cardiovascular system

    Transport of oxygen, nutrients, and waste; regulation of temperature, pH, and fluid balance; protection against pathogens and blood loss.

  • Components of the cardiovascular system

    The heart (pump), blood vessels (arteries, veins, capillaries), and blood (fluid medium).

  • Components of the lymphatic system

    Lymph fluid, lymphatic vessels, lymph nodes, and organs like the spleen, thymus, and tonsils.

  • Components of the systemic circulatory system

    Systemic arteries carry oxygenated blood from the heart; systemic veins return deoxygenated blood; capillaries are sites of exchange in tissues.

  • Components of the pulmonary circulatory system

    Pulmonary arteries carry deoxygenated blood from the heart to lungs; pulmonary veins return oxygenated blood to the heart.

  • Composition of blood

    Plasma (liquid portion) and formed elements (red blood cells, white blood cells, platelets).

  • Formed elements of blood

    Red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes).

  • Structure of red blood cells

    Biconcave shape for surface area, no nucleus in mature cells, and contain hemoglobin for oxygen transport.

  • Function of red blood cells

    Transport oxygen to tissues and remove carbon dioxide from the body.

  • Hemoglobin description

    A protein with iron that binds oxygen in red blood cells for transport.

  • Red blood cell formation (erythropoiesis)

    Occurs in bone marrow, stimulated by erythropoietin, maturing from stem cells to erythrocytes.

  • Red blood cell destruction

    Old RBCs removed by spleen and liver macrophages; hemoglobin is broken down.

  • Five types of white blood cells

    Neutrophils, eosinophils, basophils, lymphocytes, and monocytes.

  • Neutrophils function

    Most abundant WBC; perform phagocytosis to destroy pathogens.

  • Eosinophils function

    Defend against allergies and parasites.

  • Basophils function

    Release histamine to promote inflammation.

  • Lymphocytes function

    Mediate immune responses, including B and T cells.

  • Monocytes function

    Perform phagocytosis and differentiate into macrophages.

  • White blood cell formation (leukopoiesis)

    Occurs in bone marrow, regulated by growth factors, maturing from stem cells to leukocytes.

  • Platelets description

    Cell fragments from megakaryocytes that aid in blood clotting.

  • Platelet plug formation

    Platelets adhere to damaged vessels, become activated, and aggregate to form a temporary plug.

  • Blood types

    Classified by antigens on RBCs and antibodies in plasma; includes ABO and Rh systems.

  • ABO blood group system

    Blood types based on presence of A and/or B antigens on RBCs and corresponding antibodies in plasma.

  • Rh blood group system

    Classifies blood as Rh positive (presence of D antigen) or Rh negative (absence).

  • Plasma composition

    Mostly water, with proteins like albumin, globulins, fibrinogen, and solutes such as electrolytes and nutrients.

  • Blood clotting process

    Involves vasoconstriction, platelet plug formation, and the coagulation cascade leading to fibrin clot formation.

  • Clotting regulation factors

    Anticoagulants prevent clotting, procoagulants promote clotting, and fibrinolysis dissolves clots.

  • Fibrinolysis

    Activation of plasmin breaks down fibrin to dissolve blood clots.

  • Anemia

    Condition with low red blood cell count or hemoglobin, reducing oxygen-carrying capacity and causing symptoms like fatigue.

  • Leukopenia

    Low white blood cell count, increasing risk of infections due to weakened immune defense.