Textbook Question
Explain why it would be difficult for a mature multinucleate cell such as a skeletal muscle fiber to divide by mitosis.
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Ch. 4 Histology
Amerman2nd EditionHuman Anatomy & PhysiologyISBN: 9780136873822
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Table of contents
- Ch. 1 Introduction to Anatomy and Physiology26
- Ch. 2 The Chemistry of Life38
- Ch. 3 The Cell55
- Ch. 4 Histology47
- Ch. 5 The Integumentary System30
- Ch. 6 Bones and Bone Tissue36
- Ch. 7 The Skeletal System40
- Ch. 8 Articulations19
- Ch. 9 The Muscular System36
- Ch. 10 Muscle Tissue and Physiology29
- Ch. 11 Introduction to the Nervous System and Nervous Tissue28
- Ch. 12 The Central Nervous System42
- Ch. 13 The Peripheral Nervous System41
- Ch. 14 The Autonomic Nervous System and Homeostasis31
- Ch. 15 The Special Senses39
- Ch. 16 The Endocrine System42
- Ch. 17 The Cardiovascular System I: The Heart30
- Ch. 18 The Cardiovascular System II: The Blood Vessels43
- Ch. 19 Blood32
- Ch. 20 The Lymphatic System and Immunity45
- Ch. 21 The Respiratory System27
- Ch. 22 The Digestive System27
- Ch. 23 Metabolism and Nutrition7
- Ch. 24 The Urinary System39
- Ch. 25 Fluid, Electrolyte, and Acid-Base Homeostasis39
- Ch. 26 The Reproductive System10
- Ch. 27 Development and Heredity5
Chapter 4, Problem L3.B7
Predict which organelles are likely to be abundant in cells such as fibroblasts that actively produce and secrete proteins.
Verified step by step guidance1
Understand the role of fibroblasts: Fibroblasts are specialized cells responsible for producing and secreting proteins, such as collagen, which are essential for the extracellular matrix and tissue repair.
Identify the organelles involved in protein synthesis: Protein production involves the nucleus (for transcription of DNA to mRNA), ribosomes (for translation of mRNA into proteins), and the rough endoplasmic reticulum (RER), which is studded with ribosomes and specializes in synthesizing and folding proteins.
Consider the organelles involved in protein modification and packaging: The Golgi apparatus is responsible for modifying, sorting, and packaging proteins for secretion. Cells that secrete proteins in large quantities typically have an abundant and well-developed Golgi apparatus.
Account for energy requirements: Protein synthesis and secretion are energy-intensive processes. Mitochondria, the organelles responsible for ATP production, are likely to be abundant in fibroblasts to meet the high energy demands.
Conclude the likely organelles: Based on the above, fibroblasts are expected to have an abundance of rough endoplasmic reticulum, Golgi apparatus, and mitochondria to support their role in protein production and secretion.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Ribosomes
Ribosomes are cellular structures responsible for protein synthesis. They can be found either free-floating in the cytoplasm or attached to the endoplasmic reticulum. In fibroblasts, which are known for producing proteins like collagen, a high number of ribosomes is essential for meeting the demands of protein production.
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05:32
Ribosomes
Endoplasmic Reticulum (ER)
The endoplasmic reticulum is a network of membranes involved in the synthesis and processing of proteins and lipids. The rough ER, studded with ribosomes, plays a crucial role in the folding and modification of newly synthesized proteins. In fibroblasts, an abundant rough ER is indicative of their active role in protein secretion.
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06:07Endoplasmic Reticulum
Golgi Apparatus
The Golgi apparatus is an organelle that modifies, sorts, and packages proteins and lipids for secretion or delivery to other organelles. It acts as a processing center where proteins synthesized in the ER are further modified before being sent to their final destinations. In fibroblasts, a well-developed Golgi apparatus is essential for efficiently managing the high volume of protein secretion.
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06:02Golgi Apparatus
Related Practice
Textbook Question
Imagine that a disease turns the simple epithelia of the lungs, kidney tubules, and intestines into keratinized stratified squamous epithelia. What effect would this change in form have on the functions of these tissues?
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Textbook Question
Certain types of cancerous lung tumors can secrete hormones normally made by the pancreas, adrenal gland, and hypothalamus. What prevents such secretion from happening in healthy cells?
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Textbook Question
In the disease scleroderma, excessive collagen, glycosaminoglycans, and glycoproteins are produced and deposited in tissues throughout the body. Predict the effects of this disease.
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Textbook Question
In the disease pulmonary fibrosis, elastic fibers of the lung are destroyed and replaced with collagen fibers. Predict the effect this would have on breathing.
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Textbook Question
Epithelial cells of the kidneys have pumps that drive the transcellular transport of sodium ions.
Is this epithelium likely to be simple or stratified? Why?
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