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Ch. 5 The Integumentary System
Amerman - Human Anatomy & Physiology 2nd Edition
Amerman2nd EditionHuman Anatomy & PhysiologyISBN: 9780136873822Not the one you use?Change textbook
Chapter 5, Problem L3.A3a

Nguyen comes to your clinic with a mole that has recently changed in appearance. You examine the mole and note that its borders are irregular, it has a deep blue-black color, and the color is unevenly distributed throughout the mole.
What is your immediate concern? Why?

Verified step by step guidance
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Step 1: Begin by identifying the key characteristics of the mole described in the problem. These include irregular borders, deep blue-black color, and uneven color distribution. These features are clinically significant and should raise concern.
Step 2: Recall the ABCDE criteria for evaluating moles, which are commonly used to assess potential melanoma. The criteria include: A - Asymmetry, B - Border irregularity, C - Color variation, D - Diameter greater than 6mm, and E - Evolving changes in size, shape, or color.
Step 3: Compare the mole's features to the ABCDE criteria. Irregular borders and uneven color distribution align with the 'B' and 'C' criteria, while the deep blue-black color may indicate abnormal pigmentation. These findings suggest the mole could be suspicious for melanoma.
Step 4: Consider the urgency of the situation. Melanoma is a type of skin cancer that can spread rapidly if not treated early. The described changes in the mole's appearance are concerning and warrant immediate medical evaluation.
Step 5: Recommend the next steps for Nguyen. Advise a biopsy or referral to a dermatologist for further examination and diagnostic testing to confirm whether the mole is malignant. Early detection and treatment are critical for improving outcomes.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Melanoma

Melanoma is a type of skin cancer that develops from melanocytes, the cells responsible for producing melanin, which gives skin its color. It is known for its aggressive nature and potential to metastasize, making early detection crucial. The characteristics of moles, such as irregular borders and uneven color, are key indicators of melanoma, necessitating immediate medical evaluation.
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ABCDE Rule

The ABCDE rule is a guideline for identifying the warning signs of melanoma. It stands for Asymmetry, Border irregularity, Color variation, Diameter greater than 6mm, and Evolving changes. Each of these criteria helps in assessing moles for potential malignancy, and the presence of irregular borders and uneven color in Nguyen's mole raises significant concern for melanoma.
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Skin Examination

A skin examination is a thorough assessment of the skin to identify any abnormalities, such as moles or lesions that may indicate skin cancer. This process involves visual inspection and may include dermatoscopy for a more detailed view. In Nguyen's case, the examination reveals critical features that warrant immediate concern and further investigation to rule out malignancy.
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Textbook Question

Which of the following is not a function of the integument?

a. Protection from mechanical trauma

b. Thermoregulation

c. Protection from acid-base imbalances

d. Vitamin D synthesis

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Textbook Question

Which of the following correctly describes the structure of the skin?

a. It consists of the superficial epidermis, middle dermis, and deep hypodermis.

b. It consists of the superficial epidermis and deep dermis.

c. It consists of the superficial dermis and deep epidermis.

d. It consists of the superficial dermis and deep hypodermis.

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Textbook Question

After Ramon's skin came into contact with a poison ivy plant in biology lab, he developed a painful, itchy rash. However, after the skin of his colleague Cathy came into contact with snake venom in the lab, she developed no skin irritation. Poison ivy plants contain lipid-soluble oils, whereas snake venoms contain mostly water-soluble peptides. Explain why Ramon developed a rash, whereas Cathy did not.

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Textbook Question

Many antiaging skin creams contain collagen and hyaluronic acid. Manufacturers claim that the collagen and hyaluronic acid applied to the surface of the skin will be absorbed into the dermis, where they will be incorporated into dermal tissue.

What are collagen and hyaluronic acid, and what are their functions?

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Textbook Question

You are working in the emergency department when paramedics rush in with an unconscious patient. You notice that the patient is wearing athletic clothing and the skin on his face and elsewhere on his body is bright red. The paramedics tell you that he was picked up after collapsing during a bike race. What does the color of the patient's skin tell you about the probable cause of his illness? Explain.

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Textbook Question

Explain why the skin is an organ.

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