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Ch. 29 Heredity
Hoehn - Marieb Human Anatomy & Physiology, 12th edition
Hoehn, Haynes, Abbott12th EditionMarieb Human Anatomy & PhysiologyISBN: 9780138242732Not the one you use?Change textbook
Chapter 29, Problem 10

A color-blind man marries a woman with normal vision. The woman’s father was also color-blind.
(a) What is the chance that their first child will be a color-blind son? A color-blind daughter?
(b) If they have four children, what is the chance that two will be color-blind sons? (Be careful on this one.)

Verified step by step guidance
1
Step 1: Identify the inheritance pattern of color blindness. Color blindness is typically an X-linked recessive trait. This means the gene causing color blindness is located on the X chromosome, and males (XY) are more likely to express the trait because they have only one X chromosome, while females (XX) need two copies of the defective gene to be color-blind.
Step 2: Determine the genotypes of the parents. The man is color-blind, so his genotype is X\^cY (where X\^c represents the X chromosome carrying the color-blind allele). The woman has normal vision but her father was color-blind, so she must be a carrier with genotype X\^CX\^c (X\^C is the normal allele, X\^c is the color-blind allele).
Step 3: Set up a Punnett square to find the possible genotypes of their children. The mother can pass on either X\^C or X\^c, and the father can pass on either X\^c (to daughters) or Y (to sons). The combinations will give you the probabilities for each child being color-blind or not, and their sex.
Step 4: Calculate the probability for (a) the first child being a color-blind son and a color-blind daughter. For a son to be color-blind, he must inherit the Y chromosome from the father and the X\^c from the mother. For a daughter to be color-blind, she must inherit X\^c from both parents.
Step 5: For (b), use the binomial probability formula to find the chance that out of four children, exactly two are color-blind sons. First, find the probability of a child being a color-blind son (from step 4), then apply the formula: \(P(k) = \binom{n}{k} p^k (1-p)^{n-k}\) where \(n=4\), \(k=2\), and \(p\) is the probability of a color-blind son.

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

X-linked Recessive Inheritance

Color blindness is commonly inherited as an X-linked recessive trait, meaning the gene causing it is located on the X chromosome. Males (XY) with the defective gene on their single X chromosome express the trait, while females (XX) must have two copies to be affected. Females with one defective gene are carriers but usually have normal vision.
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07:23
X-Linked Inheritance

Pedigree Analysis and Carrier Status

Understanding the family history helps determine the mother's genotype. Since the woman’s father is color-blind, she must be a carrier (X^C X^c). This affects the probability calculations for their children’s genotypes and phenotypes, especially for sons who inherit their X chromosome from their mother.
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02:36
Pedigrees

Probability and Binomial Distribution

Calculating the chance of specific outcomes for multiple children involves probability rules and binomial distribution. For example, the probability of exactly two color-blind sons in four children requires combining the probability of each child being a color-blind son with the number of ways this can occur.
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Homogenous vs. Heterogenous Solutions
Related Practice