Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Noncompetitive Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Noncompetitive Inhibition

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Multiple Choice

Which of the following equilibrium expressions best represents noncompetitive inhibition of an enzyme?

E + S + I \rightleftharpoons ESI

E + S \rightleftharpoons ES;\quad E + I \rightleftharpoons EI;\quad ES + I \rightleftharpoons ESI

E + S \rightleftharpoons ES;\quad E + I \rightleftharpoons EI

E + S \rightleftharpoons ES;\quad ES + I \rightleftharpoons ESI

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Verified step by step guidance

Step 1: Begin by understanding the concept of noncompetitive inhibition. Noncompetitive inhibition occurs when an inhibitor binds to an enzyme at a site other than the active site, affecting the enzyme's activity regardless of whether the substrate is bound or not.

Step 2: Analyze the equilibrium expressions provided in the problem. Each expression represents interactions between the enzyme (E), substrate (S), and inhibitor (I). The goal is to identify which expression accurately represents noncompetitive inhibition.

Step 3: Recall that in noncompetitive inhibition, the inhibitor can bind to both the free enzyme (E) and the enzyme-substrate complex (ES). This means that equilibrium expressions should include both E + I forming EI and ES + I forming ESI.

Step 4: Compare the given options. The correct equilibrium expression for noncompetitive inhibition should include: E + S ⇌ ES; E + I ⇌ EI; ES + I ⇌ ESI. This reflects the inhibitor binding to both the free enzyme and the enzyme-substrate complex.

Step 5: Eliminate incorrect options. For example, expressions that do not include ES + I ⇌ ESI or fail to show the inhibitor binding to both E and ES are not representative of noncompetitive inhibition.