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Multiple Choice
Which of the following is considered the fastest-acting buffering mechanism in the human body?
A
The phosphate buffer system
B
The respiratory system (regulation of CO$_2$)
C
The bicarbonate buffer system
D
The protein buffer system (including hemoglobin)
Verified step by step guidance
1
Understand the concept of buffering mechanisms in the human body. Buffers help maintain pH homeostasis by neutralizing excess acids or bases. The human body has several buffering systems, including the bicarbonate buffer system, phosphate buffer system, protein buffer system, and respiratory system.
Recognize that the respiratory system regulates CO$_2$ levels in the blood. CO$_2$ combines with water to form carbonic acid (H$_2$CO$_3$), which dissociates into bicarbonate (HCO$_3^-$) and hydrogen ions (H$^+$). This process is reversible and allows the respiratory system to quickly adjust blood pH by altering the rate of CO$_2$ exhalation.
Compare the speed of action of the respiratory system to other buffering mechanisms. The respiratory system can respond within minutes to changes in blood pH by increasing or decreasing the breathing rate, making it the fastest-acting buffering mechanism.
Understand the role of other buffering systems: The bicarbonate buffer system works in conjunction with the respiratory system but relies on slower chemical equilibrium processes. The phosphate buffer system and protein buffer system (including hemoglobin) are slower and primarily act intracellularly or in specific tissues.
Conclude that the respiratory system is the fastest-acting buffering mechanism because it directly regulates CO$_2$ levels, which have a significant impact on blood pH, and it operates on a timescale of minutes compared to other systems.