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Multiple Choice
Tay-Sachs disease is caused by an inability to degrade: A.) Sphingosine. B) Gangliosides. C) Ceramide. D) Dipalmitoyl phosphatidyl choline. E) Carbohydrates.
A
Sphingosine
B
Gangliosides
C
Ceramide
D
Dipalmitoyl phosphatidyl choline
E
Carbohydrates
Verified step by step guidance
1
Understand the context of Tay-Sachs disease: It is a genetic disorder that affects the nervous system, leading to the accumulation of certain substances in the brain.
Identify the substance involved in Tay-Sachs disease: The disease is characterized by the accumulation of gangliosides, which are complex molecules found in nerve cell membranes.
Recognize the enzyme deficiency: Tay-Sachs disease is caused by a deficiency in the enzyme hexosaminidase A, which is responsible for breaking down gangliosides.
Differentiate between the options: Sphingosine, ceramide, dipalmitoyl phosphatidyl choline, and carbohydrates are not the substances that accumulate in Tay-Sachs disease. Gangliosides are the correct answer.
Conclude with the biochemical implication: The inability to degrade gangliosides due to hexosaminidase A deficiency leads to their accumulation, causing the symptoms associated with Tay-Sachs disease.