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Multiple Choice
Which of the following occurs during long-term potentiation (LTP)?
A
A decrease in neurotransmitter release from the presynaptic neuron
B
A reduction in synaptic strength between neurons
C
An increase in the number of postsynaptic glutamate receptors
D
Inhibition of calcium ion influx into the postsynaptic cell
Verified step by step guidance
1
Understand the concept of long-term potentiation (LTP): LTP is a process that strengthens synaptic connections between neurons, which is crucial for learning and memory. It involves changes in both presynaptic and postsynaptic neurons to enhance communication.
Focus on the postsynaptic changes during LTP: One key feature of LTP is the increase in the number of postsynaptic glutamate receptors, specifically AMPA receptors, which makes the postsynaptic neuron more responsive to glutamate released by the presynaptic neuron.
Recognize the role of calcium ions: During LTP, calcium ion influx into the postsynaptic cell is triggered by the activation of NMDA receptors. This influx initiates signaling pathways that lead to the insertion of additional AMPA receptors into the postsynaptic membrane.
Eliminate incorrect options: A decrease in neurotransmitter release and a reduction in synaptic strength are opposite to the strengthening effect of LTP. Similarly, inhibition of calcium ion influx would prevent the signaling pathways required for LTP.
Conclude that the correct answer is 'An increase in the number of postsynaptic glutamate receptors,' as this aligns with the mechanism of LTP and its role in enhancing synaptic strength.