Multiple Choice
Which of the following is an incorrect statement about genetic mutations?
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15. Gene Expression
Mutations
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Which type of point mutation results in a premature termination of the polypeptide chain?
A
Silent mutation
B
Nonsense mutation
C
Missense mutation
D
Frameshift mutation
Verified step by step guidance1
Understand the types of point mutations: Point mutations are changes in a single nucleotide base pair in DNA. The main types include silent, missense, nonsense, and frameshift mutations.
Define a nonsense mutation: A nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon, in the transcribed mRNA, leading to a truncated and usually nonfunctional protein.
Compare with other mutations: Silent mutations do not change the amino acid sequence of the protein. Missense mutations result in a different amino acid, potentially altering protein function. Frameshift mutations involve insertions or deletions that change the reading frame, often leading to a premature stop codon.
Identify the mutation causing premature termination: Since a nonsense mutation introduces a stop codon early in the mRNA sequence, it results in the premature termination of the polypeptide chain.
Conclude that the type of point mutation resulting in a premature termination of the polypeptide chain is a nonsense mutation.
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