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Multiple Choice
During which phase of mitosis do the centromeres of sister chromatids disjoin and the chromatids separate toward opposite poles?
A
Anaphase
B
Metaphase
C
Prophase
D
Telophase
Verified step by step guidance
1
Understand the process of mitosis: Mitosis is the division of a cell's nucleus into two genetically identical nuclei. It consists of several phases: prophase, metaphase, anaphase, and telophase.
Recall the role of sister chromatids: Sister chromatids are identical copies of a chromosome connected by a centromere. During mitosis, they must separate to ensure each daughter cell receives a complete set of chromosomes.
Focus on the phase where chromatids separate: During anaphase, the centromeres split, and the sister chromatids are pulled apart by spindle fibers toward opposite poles of the cell.
Review the other phases for comparison: In prophase, chromosomes condense and spindle fibers form. In metaphase, chromosomes align at the cell's equatorial plane. In telophase, the nuclear envelope reforms around separated chromosomes.
Conclude that the correct phase for the separation of sister chromatids is anaphase, as this is when the centromeres disjoin and chromatids move to opposite poles.