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Multiple Choice
Which of the following does not occur during mitosis?
A
Chromosome replication
B
Separation of sister chromatids
C
Formation of the mitotic spindle
D
Chromosome alignment at the metaphase plate
Verified step by step guidance
1
Understand the process of mitosis: Mitosis is a type of cell division that results in two daughter cells each having the same number and kind of chromosomes as the parent nucleus. It involves several stages: prophase, metaphase, anaphase, and telophase.
Identify the key events in each stage of mitosis: During prophase, the chromatin condenses into visible chromosomes and the mitotic spindle begins to form. In metaphase, chromosomes align at the metaphase plate. During anaphase, sister chromatids are separated and pulled to opposite poles. In telophase, the chromosomes de-condense and the nuclear envelope re-forms.
Recognize that chromosome replication does not occur during mitosis: Chromosome replication occurs during the S phase of the cell cycle, which is part of interphase, not mitosis. Mitosis is concerned with the separation and distribution of already replicated chromosomes.
Evaluate the options given: 'Separation of sister chromatids' occurs during anaphase, 'Formation of the mitotic spindle' occurs during prophase, and 'Chromosome alignment at the metaphase plate' occurs during metaphase.
Conclude that the event that does not occur during mitosis is 'Chromosome replication', as it takes place prior to mitosis during the S phase of interphase.