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Multiple Choice
Which of the following is a possible result of inhibitory postsynaptic potentials (IPSPs)?
A
Depolarization of the postsynaptic membrane
B
Opening of voltage-gated sodium channels
C
Increased likelihood of action potential generation
D
Hyperpolarization of the postsynaptic membrane
Verified step by step guidance
1
Understand the concept of inhibitory postsynaptic potentials (IPSPs): IPSPs are changes in the membrane potential of a postsynaptic neuron that make it more negative (hyperpolarized), moving it further away from the threshold needed to generate an action potential.
Recall that hyperpolarization occurs when the inside of the neuron becomes more negative relative to the outside. This can happen due to the opening of ion channels that allow negatively charged ions (e.g., Cl⁻) to enter the cell or positively charged ions (e.g., K⁺) to leave the cell.
Eliminate incorrect options: Depolarization of the postsynaptic membrane is associated with excitatory postsynaptic potentials (EPSPs), not IPSPs. Similarly, the opening of voltage-gated sodium channels and increased likelihood of action potential generation are also associated with EPSPs.
Focus on the correct option: Hyperpolarization of the postsynaptic membrane is the hallmark of IPSPs, as it decreases the likelihood of the neuron reaching the threshold for an action potential.
Conclude that the correct answer is hyperpolarization of the postsynaptic membrane, as this is the physiological effect of IPSPs on the postsynaptic neuron.