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Multiple Choice
How does the enzyme reverse transcriptase violate the central dogma of molecular biology in HIV?
A
It synthesizes RNA from a protein template.
B
It synthesizes proteins directly from DNA.
C
It synthesizes RNA from a DNA template.
D
It synthesizes DNA from an RNA template.
Verified step by step guidance
1
Begin by understanding the central dogma of molecular biology, which states that genetic information flows from DNA to RNA to protein. This is the typical pathway for gene expression in cells.
Recognize that reverse transcriptase is an enzyme found in retroviruses like HIV. Its function is to synthesize DNA from an RNA template, which is contrary to the usual flow of genetic information described by the central dogma.
Consider the implications of reverse transcriptase's activity: it allows the viral RNA genome to be converted into DNA, which can then integrate into the host cell's genome, enabling the virus to replicate within the host.
Understand that the synthesis of DNA from RNA by reverse transcriptase is a key step in the life cycle of retroviruses, allowing them to persist and propagate within the host organism.
Reflect on how this process of reverse transcription is a significant deviation from the central dogma, as it involves the reverse flow of information from RNA back to DNA, rather than the usual DNA to RNA to protein pathway.