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Multiple Choice
Which of the following is a mechanism by which some tRNAs can achieve wobble pairing?
A
Methylation of the ribose sugar
B
Addition of a poly-A tail
C
Inosine in the anticodon
D
Formation of a hairpin loop
Verified step by step guidance
1
Understand the concept of wobble pairing: Wobble pairing refers to the flexibility in base pairing between the third base of a codon in mRNA and the corresponding base in the anticodon of tRNA. This allows a single tRNA to recognize multiple codons that code for the same amino acid.
Identify the role of inosine: Inosine is a nucleoside that can be present in the anticodon of tRNA. It is known for its ability to pair with multiple bases, such as adenine (A), uracil (U), and cytosine (C), which contributes to the wobble effect.
Evaluate the options: Consider each option provided in the problem. Methylation of the ribose sugar and addition of a poly-A tail are not related to the anticodon-codon interaction. Formation of a hairpin loop is a structural feature that does not directly contribute to wobble pairing.
Focus on the correct mechanism: Inosine in the anticodon is the mechanism that allows tRNA to achieve wobble pairing, as it can pair with more than one type of base in the mRNA codon.
Conclude the analysis: Based on the understanding of wobble pairing and the role of inosine, the correct answer is that inosine in the anticodon enables some tRNAs to achieve wobble pairing.