Step 1: Understand the concept of an action potential in a neuron. An action potential is a rapid change in membrane potential that occurs when a neuron sends a signal. It involves the sequential opening and closing of voltage-gated ion channels.
Step 2: Recall the sequence of events during an action potential. At the peak of the action potential, the membrane potential is at its most positive value due to the influx of sodium ions (Na⁺) through voltage-gated sodium channels.
Step 3: Note that at the peak, voltage-gated sodium channels begin to inactivate. This prevents further sodium influx, which is necessary to stop the depolarization phase.
Step 4: Simultaneously, voltage-gated potassium channels start to open. This allows potassium ions (K⁺) to exit the cell, initiating the repolarization phase where the membrane potential becomes more negative.
Step 5: Recognize that voltage-gated calcium channels are not involved in this specific phase of the action potential. Their activation typically occurs in processes like neurotransmitter release at synaptic terminals, not during the peak of the action potential.