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Multiple Choice
Which of the following cell types has the longest cell renewal factor (CRF), indicating the slowest rate of cell turnover?
A
Hematopoietic stem cells in bone marrow
B
Epithelial cells of the intestinal lining
C
Skin epidermal keratinocytes
D
Neurons in the central nervous system
Verified step by step guidance
1
Understand the concept of cell renewal factor (CRF): CRF refers to the rate at which cells are replaced or regenerated. A longer CRF indicates slower cell turnover, meaning the cells are replaced less frequently.
Review the characteristics of each cell type: Hematopoietic stem cells in bone marrow are responsible for producing blood cells and have a relatively high turnover rate. Epithelial cells of the intestinal lining are replaced frequently due to their exposure to harsh conditions. Skin epidermal keratinocytes also regenerate quickly to maintain the skin barrier.
Consider the unique properties of neurons in the central nervous system: Neurons are highly specialized cells that generally do not divide or regenerate under normal conditions. Their CRF is extremely long because they are designed to last a lifetime without frequent replacement.
Compare the cell types: Neurons in the central nervous system have the slowest rate of cell turnover compared to the other cell types listed, as they are not actively replaced like epithelial or stem cells.
Conclude that neurons in the central nervous system have the longest cell renewal factor (CRF), indicating the slowest rate of cell turnover.