Which of the following describes mutations? Select True or False for each statement.
T/F Point mutations can occur in any DNA sequence.
T/F Frameshift mutations can occur in any DNA sequence.
T/F Neutral mutations depend on the degeneracy of the genetic code.
T/F Deleterious mutations occur only in protein-coding sequences of DNA.

If a fragment of a chromosome breaks off and then reattaches to the original chromosome but in the reverse direction, the resulting chromosomal abnormality is called

a. A deletion

b. An inversion

c. A translocation

d. A non-disjunction

Imagine discovering a loss-of-function mutation in a eukaryotic gene. You determine the gene's nucleotide sequence from the start site for transcription to the termination point of transcription and find no differences from the wild-type sequence. Explain where you think the mutation might be and how the mutation might be acting.

Which of the following mutations would be most likely to have a harmful effect on an organism?

a. A deletion of three nucleotides near the middle of a gene

b. A single nucleotide deletion in the middle of an intron

c. A single nucleotide deletion near the end of the coding sequence

d. A single nucleotide insertion downstream of, and close to, the start of the coding sequence

Explain what's wrong with this statement: All point mutations change the genotype and the phenotype.