Multiple Choice
2. If acetylcholinesterase became mutated and nonfunctional, which of the following would most likely occur in the synaptic cleft?
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7. Energy and Metabolism
Enzyme Inhibition
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The binding of an allosteric inhibitor to an enzyme causes the rate of product formation by the enzyme to decrease. Which of the following best explains why this decrease occurs?
A
The allosteric inhibitor binds to the active site, preventing the substrate from binding.
B
The allosteric inhibitor causes free energy change of the reaction to increase.
C
The allosteric inhibitor lowers the temperature of the active site.
D
The allosteric inhibitor binds to the substrate and prevents it from binding at the active site.
E
The allosteric inhibitor causes a structural change in the enzyme that prevents the substrate from binding at the active site.
Verified step by step guidance1
Understand the concept of allosteric inhibition: Allosteric inhibitors bind to a site other than the active site on an enzyme, causing a change in the enzyme's shape or conformation.
Recognize the effect of allosteric inhibition: This structural change in the enzyme can alter the active site, making it less accessible or unable to bind the substrate effectively.
Consider the options provided: Evaluate each statement to determine which one accurately describes the mechanism of allosteric inhibition.
Eliminate incorrect options: The options suggesting binding at the active site or changes in temperature or free energy are not typical effects of allosteric inhibitors.
Identify the correct explanation: The correct answer is that the allosteric inhibitor causes a structural change in the enzyme that prevents the substrate from binding at the active site.
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Enzyme Inhibition practice set
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