Multiple Choice
If a modified form of GTP that cannot be enzymatically converted to GDP were added to a culture of cells, the likely result would be __________.
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10. Cell Signaling
Classes of Signaling Receptors
0:37 minutesProblem 3
Textbook Question
Lipid-soluble signaling molecules, such as aldosterone, cross the membranes of all cells but affect only target cells because
a. Only target cells retain the appropriate DNA segments.
b. Intracellular receptors are present only in target cells.
c. Only target cells have enzymes that break down aldosterone.
d. Only in target cells is aldosterone able to initiate the phosphorylation cascade that turns genes on.
Verified step by step guidance1
Understand the nature of lipid-soluble signaling molecules: These molecules can easily cross cell membranes due to their ability to dissolve in the lipid bilayer.
Recognize that not all cells respond to lipid-soluble signals: Although these molecules can enter any cell, only specific cells, known as target cells, will respond to them.
Identify the role of intracellular receptors: Target cells have specific receptors inside the cell that bind to the signaling molecule. This binding is crucial for the signal to have an effect.
Consider the options given: Evaluate each option based on your understanding of how lipid-soluble signaling molecules work. Focus on the presence of intracellular receptors in target cells.
Conclude which option correctly explains why only target cells are affected: The correct answer involves the presence of intracellular receptors in target cells, which bind the signaling molecule and initiate a cellular response.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lipid-soluble signaling molecules
Lipid-soluble signaling molecules, such as steroid hormones, can easily pass through cell membranes due to their hydrophobic nature. These molecules typically bind to intracellular receptors, which are located within the cytoplasm or nucleus of target cells, allowing them to directly influence gene expression and cellular function.
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Intracellular receptors
Intracellular receptors are proteins located inside the cell, either in the cytoplasm or nucleus, that bind to lipid-soluble signaling molecules. Upon binding, these receptors often act as transcription factors, directly affecting gene expression by interacting with specific DNA sequences, thus influencing cellular responses.
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Target cells
Target cells are specific cells that respond to signaling molecules due to the presence of specific receptors. In the context of lipid-soluble molecules like aldosterone, only target cells possess the intracellular receptors necessary for binding the molecule, which allows them to initiate specific cellular responses, such as changes in gene expression.
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