Table of contents
- 1. Introduction to Biology2h 42m
- 2. Chemistry3h 37m
- 3. Water1h 26m
- 4. Biomolecules2h 23m
- 5. Cell Components2h 26m
- 6. The Membrane2h 31m
- 7. Energy and Metabolism2h 0m
- 8. Respiration2h 40m
- 9. Photosynthesis2h 49m
- 10. Cell Signaling59m
- 11. Cell Division2h 47m
- 12. Meiosis2h 0m
- 13. Mendelian Genetics4h 44m
- Introduction to Mendel's Experiments7m
- Genotype vs. Phenotype17m
- Punnett Squares13m
- Mendel's Experiments26m
- Mendel's Laws18m
- Monohybrid Crosses19m
- Test Crosses14m
- Dihybrid Crosses20m
- Punnett Square Probability26m
- Incomplete Dominance vs. Codominance20m
- Epistasis7m
- Non-Mendelian Genetics12m
- Pedigrees6m
- Autosomal Inheritance21m
- Sex-Linked Inheritance43m
- X-Inactivation9m
- 14. DNA Synthesis2h 27m
- 15. Gene Expression3h 6m
- 16. Regulation of Expression3h 31m
- Introduction to Regulation of Gene Expression13m
- Prokaryotic Gene Regulation via Operons27m
- The Lac Operon21m
- Glucose's Impact on Lac Operon25m
- The Trp Operon20m
- Review of the Lac Operon & Trp Operon11m
- Introduction to Eukaryotic Gene Regulation9m
- Eukaryotic Chromatin Modifications16m
- Eukaryotic Transcriptional Control22m
- Eukaryotic Post-Transcriptional Regulation28m
- Eukaryotic Post-Translational Regulation13m
- 17. Viruses37m
- 18. Biotechnology2h 58m
- 19. Genomics17m
- 20. Development1h 5m
- 21. Evolution3h 1m
- 22. Evolution of Populations3h 53m
- 23. Speciation1h 37m
- 24. History of Life on Earth2h 6m
- 25. Phylogeny2h 31m
- 26. Prokaryotes4h 59m
- 27. Protists1h 12m
- 28. Plants1h 22m
- 29. Fungi36m
- 30. Overview of Animals34m
- 31. Invertebrates1h 2m
- 32. Vertebrates50m
- 33. Plant Anatomy1h 3m
- 34. Vascular Plant Transport1h 2m
- 35. Soil37m
- 36. Plant Reproduction47m
- 37. Plant Sensation and Response1h 9m
- 38. Animal Form and Function1h 19m
- 39. Digestive System1h 10m
- 40. Circulatory System1h 49m
- 41. Immune System1h 12m
- 42. Osmoregulation and Excretion50m
- 43. Endocrine System1h 4m
- 44. Animal Reproduction1h 2m
- 45. Nervous System1h 55m
- 46. Sensory Systems46m
- 47. Muscle Systems23m
- 48. Ecology3h 11m
- Introduction to Ecology20m
- Biogeography14m
- Earth's Climate Patterns50m
- Introduction to Terrestrial Biomes10m
- Terrestrial Biomes: Near Equator13m
- Terrestrial Biomes: Temperate Regions10m
- Terrestrial Biomes: Northern Regions15m
- Introduction to Aquatic Biomes27m
- Freshwater Aquatic Biomes14m
- Marine Aquatic Biomes13m
- 49. Animal Behavior28m
- 50. Population Ecology3h 41m
- Introduction to Population Ecology28m
- Population Sampling Methods23m
- Life History12m
- Population Demography17m
- Factors Limiting Population Growth14m
- Introduction to Population Growth Models22m
- Linear Population Growth6m
- Exponential Population Growth29m
- Logistic Population Growth32m
- r/K Selection10m
- The Human Population22m
- 51. Community Ecology2h 46m
- Introduction to Community Ecology2m
- Introduction to Community Interactions9m
- Community Interactions: Competition (-/-)38m
- Community Interactions: Exploitation (+/-)23m
- Community Interactions: Mutualism (+/+) & Commensalism (+/0)9m
- Community Structure35m
- Community Dynamics26m
- Geographic Impact on Communities21m
- 52. Ecosystems2h 36m
- 53. Conservation Biology24m
40. Circulatory System
Heart Physiology
Problem 3
Textbook Question
When the doctor listened to Janet's heart, he heard 'lub-hiss, lub-hiss' instead of the normal 'lub-dup' sounds. The hiss is most likely due to _________ . (Explain your answer.)
a. A defective atrioventricular (AV) valve
b. A damaged pacemaker (SA node)
c. A defective semilunar valve
d. High blood pressure

1
Step 1: Understand the normal heart sounds 'lub-dup'. The 'lub' sound is caused by the closing of the atrioventricular (AV) valves (tricuspid and mitral valves) during ventricular contraction (systole). The 'dup' sound is caused by the closing of the semilunar valves (aortic and pulmonary valves) during ventricular relaxation (diastole).
Step 2: Analyze the abnormal sound 'lub-hiss'. The 'hiss' indicates a potential issue with valve closure, as it suggests turbulent blood flow or leakage (regurgitation) through a valve that is not closing properly.
Step 3: Evaluate the options provided. A defective atrioventricular (AV) valve would cause abnormal sounds during the 'lub' phase, but the hiss is heard after the 'lub' sound. A damaged pacemaker (SA node) would affect the rhythm of the heartbeat, not the valve sounds. High blood pressure could strain the heart but does not directly cause a 'hiss' sound.
Step 4: Focus on the semilunar valves. A defective semilunar valve could fail to close properly during diastole, leading to regurgitation of blood and producing the 'hiss' sound after the 'lub' phase.
Step 5: Conclude that the abnormal 'lub-hiss' sound is most likely due to a defective semilunar valve, as this aligns with the timing and nature of the sound described in the problem.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Heart Sounds
The heart produces sounds during its cycle, primarily 'lub' and 'dup.' The 'lub' sound is caused by the closure of the atrioventricular (AV) valves, while the 'dup' sound results from the closure of the semilunar valves. Abnormal sounds, such as a 'hiss,' can indicate issues with these valves or other cardiac functions.
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Heart Physiology
Atrioventricular (AV) Valve Function
The AV valves, which include the tricuspid and mitral valves, separate the atria from the ventricles. They ensure unidirectional blood flow from the atria to the ventricles. A defect in these valves can lead to regurgitation, causing abnormal heart sounds like a 'hiss' due to turbulent blood flow.
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Functional Groups
Semilunar Valve Function
The semilunar valves, comprising the aortic and pulmonary valves, control blood flow from the ventricles into the aorta and pulmonary artery, respectively. If these valves are defective, they may not close properly, leading to backflow or turbulence, which can also produce abnormal heart sounds, such as a 'hiss.'
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Multiple Choice
Which of the following decreases blood pressure?
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