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Multiple Choice
Where are populations with high frequencies of the sickle-cell trait most commonly found?
A
In populations living near the Arctic Circle
B
In areas with high altitudes, such as the Andes mountains
C
In northern European countries with cold climates
D
In regions where malaria is or was historically prevalent, such as sub-Saharan Africa
Verified step by step guidance
1
Understand the sickle-cell trait: The sickle-cell trait is a genetic condition caused by a mutation in the hemoglobin gene. Individuals with one copy of the sickle-cell allele (heterozygous) have some resistance to malaria, a disease caused by Plasmodium parasites transmitted by mosquitoes.
Recognize the relationship between malaria and the sickle-cell trait: The sickle-cell trait provides a selective advantage in regions where malaria is prevalent. This is because the altered hemoglobin in individuals with the trait makes it harder for the malaria parasite to survive and reproduce within red blood cells.
Identify regions with high malaria prevalence: Malaria is most common in tropical and subtropical regions, particularly sub-Saharan Africa, parts of South Asia, and some areas of Central and South America. Historically, these regions have had high rates of malaria transmission.
Connect the sickle-cell trait to population genetics: Over generations, natural selection has increased the frequency of the sickle-cell allele in populations living in areas with high malaria prevalence. This is an example of balanced polymorphism, where the heterozygous condition provides a survival advantage.
Conclude that populations with high frequencies of the sickle-cell trait are found in regions where malaria is or was historically prevalent, such as sub-Saharan Africa, rather than areas with cold climates or high altitudes.