Multiple Choice
What role do phosphatases play in signal transduction pathways?
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10. Cell Signaling
Signal Amplification
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A mutation in the active site of adenylyl cyclase that inactivates it would most likely lead to __________.
A
an increase in the amount of cAMP present in the cell
B
higher activity of protein kinase A
C
reduced binding of adenylyl cyclase to protein kinase A
D
increased binding of adenylyl cyclase to the G protein that activates it
E
lower activity of protein kinase A
Verified step by step guidance1
Understand the role of adenylyl cyclase: Adenylyl cyclase is an enzyme that converts ATP to cyclic AMP (cAMP), which is a secondary messenger involved in signal transduction pathways.
Recognize the impact of cAMP: cAMP activates protein kinase A (PKA), which then phosphorylates various target proteins to elicit cellular responses.
Consider the effect of inactivating adenylyl cyclase: If a mutation inactivates adenylyl cyclase, it would lead to a decrease in the production of cAMP.
Analyze the consequences of reduced cAMP levels: With lower levels of cAMP, there would be less activation of protein kinase A.
Conclude the outcome: Since protein kinase A activity is dependent on cAMP, a decrease in cAMP due to inactive adenylyl cyclase would result in lower activity of protein kinase A.
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