Multiple Choice
Which of the following processes will be affected by a deficiency in pyruvate carboxylase?
8. Respiration
Pyruvate Oxidation
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Which of the following events accompanies the conversion of pyruvate to acetyl CoA before the citric acid cycle?
A
Formation of CO2 and synthesis of ATP
B
Release of CO2 and release of coenzyme A
C
Removal of coenzyme A
D
Regeneration of NAD+
E
Release of CO2 and synthesis of NADH
Verified step by step guidance1
Understand that pyruvate conversion to acetyl CoA is a preparatory step before entering the citric acid cycle, also known as the Krebs cycle.
Recognize that during this conversion, pyruvate undergoes oxidative decarboxylation, which involves the removal of a carbon atom from pyruvate, releasing it as carbon dioxide (CO2).
Identify that this process is catalyzed by the pyruvate dehydrogenase complex, which facilitates the conversion of pyruvate into acetyl CoA.
Note that during this conversion, NAD+ is reduced to NADH, capturing high-energy electrons for use in the electron transport chain.
Conclude that the correct events accompanying the conversion of pyruvate to acetyl CoA are the release of CO2 and the synthesis of NADH, not ATP.
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