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Multiple Choice
In the context of cell signaling, which of the following best explains why an infant might become unresponsive to a hormone after repeated exposure?
A
Increased synthesis of the hormone by endocrine glands
B
Enhanced sensitivity of target cells to the hormone
C
Activation of secondary messenger pathways
D
Downregulation of hormone receptors on target cells
Verified step by step guidance
1
Understand the concept of hormone signaling: Hormones are chemical messengers that bind to specific receptors on target cells to elicit a response. The number of receptors on the target cell surface can influence the cell's sensitivity to the hormone.
Define downregulation: Downregulation refers to the process by which a cell decreases the number of receptors on its surface in response to prolonged or excessive exposure to a hormone. This is a protective mechanism to prevent overstimulation.
Relate downregulation to the problem: If an infant is repeatedly exposed to high levels of a hormone, the target cells may reduce the number of hormone receptors through downregulation. This would make the cells less responsive to the hormone over time.
Eliminate incorrect options: Increased synthesis of the hormone would lead to higher hormone levels, but it does not explain the reduced responsiveness. Enhanced sensitivity of target cells would increase responsiveness, not decrease it. Activation of secondary messenger pathways is part of the signaling process but does not directly explain reduced responsiveness.
Conclude with the correct explanation: The best explanation for the infant becoming unresponsive to the hormone is the downregulation of hormone receptors on the target cells, which reduces the cell's ability to respond to the hormone despite its presence.