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Multiple Choice
In the Krebs cycle, which molecule is regenerated at the end of each cycle to allow the process to continue?
A
Succinate
B
Citrate
C
Oxaloacetate
D
Acetyl-CoA
Verified step by step guidance
1
Step 1: Begin by understanding the Krebs cycle (also known as the citric acid cycle). It is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins.
Step 2: Recall that the cycle starts with the combination of acetyl-CoA and oxaloacetate to form citrate. This reaction is catalyzed by the enzyme citrate synthase.
Step 3: Follow the sequence of reactions in the cycle. Citrate undergoes several transformations, including isomerization, decarboxylation, and oxidation, leading to the production of energy-rich molecules like NADH and FADH2, as well as intermediates such as succinate.
Step 4: At the end of the cycle, oxaloacetate is regenerated from intermediates like malate through oxidation. This regeneration is crucial because oxaloacetate is required to combine with acetyl-CoA to start the cycle again.
Step 5: Understand that oxaloacetate is the molecule that is regenerated at the end of each cycle, ensuring the Krebs cycle can continue repeatedly as long as acetyl-CoA is available.