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Multiple Choice
Which hemoglobin genotype has the highest fitness in an area of high malaria infection?
A
SS
B
AC
C
AS
D
AA
Verified step by step guidance
1
Understand the context: In areas with high malaria infection, certain hemoglobin genotypes provide a survival advantage due to their resistance to malaria.
Identify the genotypes: The genotypes in question are SS, AC, AS, and AA. Each represents a different combination of alleles for hemoglobin.
Consider the effects of each genotype: SS (sickle cell disease) is generally disadvantageous due to health complications. AA (normal hemoglobin) does not provide malaria resistance. AC is not typically associated with malaria resistance.
Focus on the AS genotype: The AS genotype, known as sickle cell trait, provides a balance. Individuals with AS have some sickle-shaped cells but generally do not suffer from severe symptoms and have increased resistance to malaria.
Conclude the analysis: In areas with high malaria infection, the AS genotype has the highest fitness because it offers a survival advantage by providing resistance to malaria without the severe health issues associated with SS.