A man has six fingers on each hand and six toes on each foot. His wife and their daughter have the normal number of digits. Remember that extra digits is a dominant trait. What fraction of this couple's children would be expected to have extra digits?
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13. Mendelian Genetics
Punnett Square Probability
Problem 7
Textbook Question
The genotype of F1 individuals in a tetrahybrid cross is AaBbCcDd. Assuming independent assortment of these four genes, what are the probabilities that F2 offspring will have the following genotypes?
a. aabbccdd
b. AaBbCcDd
c. AABBCCDD
d. AaBBccDd
e. AaBBCCdd

1
Understand that independent assortment means each gene pair segregates independently during gamete formation. This is based on Mendel's law of independent assortment.
For each gene pair, calculate the probability of inheriting a specific allele combination. For example, the probability of inheriting 'aa' from 'Aa' is 1/4, since each parent can contribute either 'A' or 'a'.
Apply the probability rule for independent events: multiply the probabilities of each independent event to find the overall probability of a genotype. For example, the probability of 'aabbccdd' is the product of the probabilities of 'aa', 'bb', 'cc', and 'dd'.
Repeat the calculation for each requested genotype. For instance, for 'AaBbCcDd', calculate the probability of inheriting 'Aa' (1/2), 'Bb' (1/2), 'Cc' (1/2), and 'Dd' (1/2), then multiply these probabilities.
Consider the dominance and recessiveness of alleles if needed, but in this case, focus on the probability of allele combinations rather than phenotypic expression.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Independent Assortment
Independent assortment is a principle of Mendelian genetics stating that alleles of different genes segregate independently during gamete formation. This means the inheritance of one trait generally does not affect the inheritance of another, allowing for various combinations of alleles in offspring. In a tetrahybrid cross, each gene pair segregates independently, leading to diverse genotypic possibilities.
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Independent Assortment
Probability in Genetics
Probability in genetics involves calculating the likelihood of specific genotypes or phenotypes appearing in offspring. This is done using the principles of Mendelian inheritance, where the probability of inheriting a particular allele from each parent is considered. For a tetrahybrid cross, probabilities are calculated by multiplying the chances of inheriting each allele independently.
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Punnett Square Probability
Punnett Square
A Punnett square is a diagram used to predict the genotypes of offspring from a particular genetic cross. It helps visualize how alleles from each parent combine, showing all possible genetic outcomes. In a tetrahybrid cross, a Punnett square can be complex, but it systematically illustrates the independent assortment and combination of alleles for multiple genes.
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