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Ch. 11 - Cell-Cell Interactions
Freeman - Biological Science 7th Edition
Freeman7th EditionBiological ScienceISBN: 9783584863285Not the one you use?Change textbook
All textbooksFreeman 7th EditionCh. 11 - Cell-Cell InteractionsProblem 9b
Chapter 11, Problem 9b

Steroid hormones, like most lipid-soluble signaling molecules, are processed directly. How does the absence of a signal transduction cascade in the processing of steroid hormones affect (b) signal regulation?

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1
Understand that steroid hormones are lipid-soluble, allowing them to pass through cell membranes easily and bind directly to intracellular receptors.
Recognize that the absence of a signal transduction cascade means that steroid hormones do not require a series of intermediary steps to relay their signal inside the cell.
Consider how direct binding to receptors affects signal regulation: the response is typically more straightforward and less modulated by other cellular components compared to pathways involving multiple steps.
Reflect on the implications of this direct action: the signal is less subject to amplification or attenuation, which can occur in multi-step cascades, leading to a more consistent and sustained response.
Conclude that while the direct pathway allows for rapid and specific responses, it may limit the cell's ability to finely tune the signal compared to more complex pathways with multiple regulatory points.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Steroid Hormones

Steroid hormones are lipid-soluble molecules derived from cholesterol, which can easily pass through cell membranes. Unlike peptide hormones, they do not require surface receptors and can directly interact with intracellular receptors, influencing gene expression and cellular function. This direct interaction allows for rapid and specific responses within target cells.
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Signal Transduction Cascade

A signal transduction cascade is a series of molecular events initiated by the binding of a signaling molecule to a receptor, often involving multiple steps and amplification of the signal. This process typically involves secondary messengers and protein modifications, allowing for complex regulation and integration of signals, which can modulate cellular responses in a controlled manner.
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Signal Regulation

Signal regulation refers to the mechanisms that control the intensity, duration, and specificity of a cellular response to a signaling molecule. In the absence of a signal transduction cascade, as seen with steroid hormones, regulation is primarily achieved through receptor availability, hormone concentration, and direct gene expression changes, leading to a more straightforward but less modulated response compared to cascades.
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Related Practice
Textbook Question

What is the significance of the observation that many signal transduction pathways create a network, where they intersect or overlap?

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Textbook Question
Steroid hormones, like most lipid-soluble signaling molecules, are processed directly. How does the absence of a signal transduction cascade in the processing of steroid hormones affect (b) signal regulation?
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Textbook Question

Steroid hormones, like most lipid-soluble signaling molecules, are processed directly. How does the absence of a signal transduction cascade in the processing of steroid hormones affect (a) signal amplification?

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Textbook Question

Steroid hormones, like most lipid-soluble signaling molecules, are processed directly. How does the absence of a signal transduction cascade in the processing of steroid hormones affect (c) the cellular response that is possible?

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Textbook Question

Suppose you have an antibody that binds to the receptor tyrosine kinase illustrated in Figure 11.16. When you add this antibody to the cell, you find that it activates the cell response, even when no signaling molecule is present. Explain this result.

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