Multiple Choice
In eukaryotic cells, can RNA leave the nucleus, and if so, which statement best describes how mRNA is exported?
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5. DNA to RNA to Protein
mRNA Export and Nuclear Structures
Multiple Choice
In a typical eukaryotic cell, where does mature mRNA go immediately after it exits the nucleus through a nuclear pore complex?
A
Directly into the mitochondrial matrix to be translated by mitochondrial ribosomes
B
Into the cytosol, where it can associate with ribosomes for translation
C
Into the Golgi lumen to be packaged into secretory vesicles
D
Into the nucleolus, where it is processed into rRNA
Verified step by step guidance1
Understand the process of mRNA maturation and export: In eukaryotic cells, mature mRNA is synthesized and processed inside the nucleus, including splicing and addition of a 5' cap and poly-A tail.
Recognize the role of the nuclear pore complex: Mature mRNA exits the nucleus through nuclear pore complexes, which serve as gateways between the nucleus and the cytoplasm.
Identify the destination of mature mRNA after nuclear export: Once in the cytoplasm, mature mRNA is available to associate with ribosomes for translation into proteins.
Eliminate incorrect options by considering cellular compartments: The mitochondrial matrix is involved in mitochondrial gene expression, not typical nuclear mRNA; the Golgi lumen is for protein modification and sorting, not mRNA transport; the nucleolus is the site of rRNA synthesis and ribosome assembly, not mRNA processing.
Conclude that mature mRNA goes into the cytosol immediately after exiting the nucleus, where it can be translated by cytoplasmic ribosomes.
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