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Multiple Choice
G-protein coupled receptors are examples of what type of effector pathway?
A
Direct gene activation pathway
B
Enzyme-linked receptor pathway
C
Ion channel-linked pathway
D
Second messenger pathway
Verified step by step guidance
1
Understand the role of G-protein coupled receptors (GPCRs): GPCRs are a large family of membrane receptors that transmit signals from extracellular molecules (ligands) to intracellular signaling pathways.
Recognize the mechanism of GPCR activation: When a ligand binds to a GPCR, it activates an associated G-protein by causing the exchange of GDP for GTP on the G-protein's alpha subunit.
Identify the downstream signaling: The activated G-protein can interact with various effectors, such as enzymes (e.g., adenylyl cyclase or phospholipase C), which generate second messengers like cyclic AMP (cAMP) or inositol trisphosphate (IP3).
Clarify the term 'second messenger pathway': Second messengers are small intracellular molecules that amplify and propagate the signal initiated by the GPCR. Examples include cAMP, IP3, and calcium ions.
Conclude that GPCRs are associated with second messenger pathways, as their primary function is to activate intracellular signaling cascades through the production of these second messengers.