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Multiple Choice
In the innate immune response, circulating monocytes that leave the bloodstream and enter tissues typically differentiate into which cell type?
A
Macrophages
B
Plasma cells
C
Eosinophils
D
Neutrophils
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1
Understand the role of monocytes in the innate immune system: Monocytes are a type of white blood cell circulating in the bloodstream that can migrate into tissues when needed.
Recall that once monocytes leave the bloodstream and enter tissues, they undergo differentiation, meaning they change into a different, more specialized cell type.
Identify the specialized cell type monocytes become in tissues: They differentiate into macrophages, which are large phagocytic cells that engulf pathogens and debris.
Recognize that plasma cells are differentiated B cells involved in antibody production, eosinophils are granulocytes involved in combating parasites and allergic responses, and neutrophils are another type of granulocyte involved in acute inflammation but do not arise from monocytes.
Conclude that the correct answer is macrophages, as they are the tissue-resident cells derived from monocytes that play a key role in innate immunity.