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Multiple Choice
Which of the following statements accurately describes receptor tyrosine kinases (RTKs)?
A
RTKs are G protein-coupled receptors that activate second messengers.
B
RTKs are transmembrane proteins that phosphorylate tyrosine residues upon ligand binding.
C
RTKs are intracellular receptors that bind steroid hormones.
D
RTKs function primarily as ion channels in the plasma membrane.
Verified step by step guidance
1
Understand the role of receptor tyrosine kinases (RTKs) in cell signaling. RTKs are a class of transmembrane proteins that play a critical role in signal transduction by phosphorylating tyrosine residues on themselves or other proteins upon ligand binding.
Eliminate the incorrect option: 'RTKs are G protein-coupled receptors that activate second messengers.' RTKs are not G protein-coupled receptors (GPCRs). GPCRs use G proteins and second messengers like cAMP, whereas RTKs directly phosphorylate tyrosine residues.
Eliminate the incorrect option: 'RTKs are intracellular receptors that bind steroid hormones.' Intracellular receptors typically bind hydrophobic molecules like steroid hormones and are located inside the cell, whereas RTKs are transmembrane proteins located on the cell surface.
Eliminate the incorrect option: 'RTKs function primarily as ion channels in the plasma membrane.' RTKs do not function as ion channels. Ion channels allow the passage of ions across the membrane, while RTKs are involved in phosphorylation and signal transduction.
Conclude that the correct statement is: 'RTKs are transmembrane proteins that phosphorylate tyrosine residues upon ligand binding.' This accurately describes the structure and function of RTKs in cell signaling.