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Multiple Choice
In the context of the G1 phase checkpoint and cell-cycle control, what type of cell is most likely to exit G1 and enter the G0 phase (a quiescent, non-dividing state)?
A
A cell actively undergoing mitosis, which transitions from M phase into G1 rather than G0
B
A cell in S phase that temporarily pauses DNA replication and enters G0
C
A rapidly dividing embryonic stem cell, which proceeds directly from G1 into S phase
D
A terminally differentiated cell such as a neuron, which has exited the cell cycle into a long-term quiescent state
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Verified step by step guidance
1
Understand the role of the G1 phase checkpoint: it assesses whether the cell has the necessary resources and conditions to proceed with DNA synthesis (S phase) or to exit the cycle into a resting state (G0).
Recognize that cells in active division, such as those in M phase or S phase, are committed to continuing the cell cycle and do not typically enter G0 at these stages.
Identify that rapidly dividing cells, like embryonic stem cells, usually bypass G0 and proceed directly from G1 to S phase to support growth and development.
Learn that terminally differentiated cells, such as neurons, have permanently exited the cell cycle and enter G0, a quiescent state where they no longer divide.
Conclude that the type of cell most likely to exit G1 and enter G0 is a terminally differentiated cell, which has left the cycle for long-term quiescence.